Plasmepsin: Difference between revisions

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Plasmepsins are a class of at least 10 enzymes produced by the plasmodium parasite. Through their haemoglobin-degrading activity, they are an important cause of symptoms in malaria sufferers.

Plasmepsins are aspartic acid proteases, which means their active site contains two aspartic acid residue in their active site. These two aspartic acid residue act respectively as proton donor and proton acceptor, catalysing the hydrolysis of peptide bond in proteins.

The name plasmepsin may come from plasmodium (the organism) and pepsin (a common aspartic acid protease with similar molecular structure).

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 '''Plasmepsins''' are a class of at least 10 enzymes produced by the [[plasmodium]] parasite. Through their haemoglobin-degrading activity, they are an important cause of symptoms in [[malaria]] sufferers.
-Plasmepsins are [[aspartic acid]] [[proteases]], which means they degrade other proteins by attacking an aspartic acid [[amino-acid|residue]].
+Plasmepsins are [[aspartic acid]] [[proteases]], which means their active site contains two [[aspartic acid]] [[amino-acid|residue]] in their active site.
+These two [[aspartic acid]] [[amino-acid|residue]] act respectively as proton donor and proton acceptor, catalysing the hydrolysis of [[peptide bond]] in [[proteins]].
 The name ''plasmepsin'' may come from ''plasmodium'' (the organism) and ''pepsin'' (a common aspartic acid protease with similar molecular structure).