Endoplasmic reticulum resident protein: Difference between revisions

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ER retention refers to proteins that are retained in the endoplasmic reticulum, or ER, after folding; these are known as ER resident proteins.

Their localization to the ER often depends on certain sequences of amino acids located at the N-terminus or C-terminus. The classical ER retention signal is the C-terminal KDEL sequence for lumen bound proteins and KKXX for transmembrane localization. These signals allow for retrieval from the Golgi apparatus, effectively maintaining the protein in the ER.^[1] Other mechanisms for ER retention are being studied but are not as well characterized as signal retention.

ER retention receptors

References

^ Mariano Stornaiuolo, Lavinia V. Lotti, Nica Borgese, Maria-Rosaria Torrisi, Giovanna Mottola, Gianluca Martire, and Stefano Bonatti (March 2003). "KDEL and KKXX Retrieval Signals Appended to the Same Reporter Protein Determine Different Trafficking between Endoplasmic Reticulum, Intermediate Compartment, and Golgi Complex". Molecular Biology of the Cell. 14 (3): 889–902. doi:10.1091/mbc.E02-08-0468.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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[1] Mariano Stornaiuolo, Lavinia V. Lotti, Nica Borgese, Maria-Rosaria Torrisi, Giovanna Mottola, Gianluca Martire, and Stefano Bonatti (March 2003). "KDEL and KKXX Retrieval Signals Appended to the Same Reporter Protein Determine Different Trafficking between Endoplasmic Reticulum, Intermediate Compartment, and Golgi Complex". Molecular Biology of the Cell. 14 (3): 889–902. doi:10.1091/mbc.E02-08-0468.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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 '''ER retention''' refers to [[proteins]] that are retained in the [[endoplasmic reticulum]], or ER, after [[protein folding|folding]]; these are known as ER resident proteins.
-Their localization to the ER often depends on certain sequences of [[amino acids]] located at the [[N-terminal]] or [[C-terminal]].  The classical ER retention signal is the C-terminal [[KDEL sequence]] for lumen bound proteins and [[KKXX (amino acid sequence)|KKXX]] for transmembrane localization. These signals allow for retrieval from the [[Golgi apparatus]], effectively maintaining the protein in the ER.<ref>{{cite journal| author=Mariano Stornaiuolo, Lavinia V. Lotti, Nica Borgese, Maria-Rosaria Torrisi, Giovanna Mottola, Gianluca Martire, and Stefano Bonatti|date=March 2003| title=KDEL and KKXX Retrieval Signals Appended to the Same Reporter Protein Determine Different Trafficking between Endoplasmic Reticulum, Intermediate Compartment, and Golgi Complex| journal=Molecular Biology of the Cell| volume=14|issue=3| pages=889–902| doi=10.1091/mbc.E02-08-0468}}</ref> Other mechanisms for ER retention are being studied but are not as well characterized as signal retention.
+Their localization to the ER often depends on certain sequences of [[amino acids]] located at the [[N-terminus]] or [[C-terminus]].  The classical ER retention signal is the C-terminal [[KDEL sequence]] for lumen bound proteins and [[KKXX (amino acid sequence)|KKXX]] for transmembrane localization. These signals allow for retrieval from the [[Golgi apparatus]], effectively maintaining the protein in the ER.<ref>{{cite journal| author=Mariano Stornaiuolo, Lavinia V. Lotti, Nica Borgese, Maria-Rosaria Torrisi, Giovanna Mottola, Gianluca Martire, and Stefano Bonatti|date=March 2003| title=KDEL and KKXX Retrieval Signals Appended to the Same Reporter Protein Determine Different Trafficking between Endoplasmic Reticulum, Intermediate Compartment, and Golgi Complex| journal=Molecular Biology of the Cell| volume=14|issue=3| pages=889–902| doi=10.1091/mbc.E02-08-0468}}</ref> Other mechanisms for ER retention are being studied but are not as well characterized as signal retention.
 ==ER retention receptors==