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Protein-coding gene in the species Homo sapiens
AH receptor-interacting protein (AIP ) also known as aryl hydrocarbon receptor-interacting protein , immunophilin homolog ARA9 , or HBV X-associated protein 2 (XAP-2 ) is a protein that in humans is encoded by the AIP gene .[ 5] [ 6] [ 7] FKBP family.
AIP may play a positive role in aryl hydrocarbon receptor -mediated signalling possibly by influencing its receptivity for ligand and/or its nuclear targeting. AIP is the cellular negative regulator of the hepatitis B virus (HBV) X protein.[ 5] [ 8] [ 9]
Mutations and role in disease [ edit ] AIP mutations may be the cause of a familial form of acromegaly , familial isolated pituitary adenoma (FIPA). Somatotropinomas (i.e. GH -producing pituitary adenomas ), sometimes associated with prolactinomas , are present in most AIP mutated patients.[ 10]
AIP has been shown to interact with the aryl hydrocarbon receptor ,[ 7] [ 11] [ 12] peroxisome proliferator-activated receptor alpha [ 13] aryl hydrocarbon receptor nuclear translocator .[ 7] [ 14] [ 8]
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"Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity" . Mol. Cell. Biol . 18 (2): 978–88. doi :10.1128/MCB.18.2.978 . PMC 108810 PMID 9447995 . Carver LA, LaPres JJ, Jain S, et al. (1999). "Characterization of the Ah receptor-associated protein, ARA9" . J. Biol. Chem . 273 (50): 33580–7. doi :10.1074/jbc.273.50.33580 PMID 9837941 . Gadelha MR, Une KN, Rohde K, et al. (2000). "Isolated familial somatotropinomas: establishment of linkage to chromosome 11q13.1-11q13.3 and evidence for a potential second locus at chromosome 2p16-12" . J. Clin. Endocrinol. Metab . 85 (2): 707–14. doi :10.1210/jcem.85.2.6386 PMID 10690880 . Petrulis JR, Hord NG, Perdew GH (2001). "Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2" . J. Biol. Chem . 275 (48): 37448–53. doi :10.1074/jbc.M006873200 PMID 10986286 . 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