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Chemical compound
Pharmaceutical compound
Impromidine ATC code
2-[3-(1H -imidazol-5-yl)propyl]-1-[2-[(5-methyl-1H -imidazol-4-yl)methylsulfanyl]ethyl]guanidine
CAS Number PubChem CID IUPHAR/BPS ChemSpider UNII ChEMBL CompTox Dashboard (EPA ) Formula C 14 H 23 N 7 S Molar mass −1 3D model (JSmol )
Cc1[nH]cnc1CSCCNC(=N)NCCCc2c[nH]cn2
InChI=1S/C14H23N7S/c1-11-13(21-10-19-11)8-22-6-5-18-14(15)17-4-2-3-12-7-16-9-20-12/h7,9-10H,2-6,8H2,1H3,(H,16,20)(H,19,21)(H3,15,17,18)
N Key:MURRAGMMNAYLNA-UHFFFAOYSA-N
N N Y (what is this?) (verify)
Impromidine (INN ) is a highly potent and specific histamine H2 receptor agonist .[ 1]
It has been used diagnostically as a gastric secretion indicator.
^ Durant G, Duncan W, Ganellin C, Parsons M, Blakemore R, Rasmussen A (1978). "Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors". Nature 276 (5686): 403– 5. doi :10.1038/276403a0 . PMID 714166 . S2CID 4242863 .
H1
Agonists Antagonists
Others: Atypical antipsychotics (e.g., aripiprazole , asenapine , brexpiprazole , brilaroxazine , clozapine , iloperidone , olanzapine , paliperidone , quetiapine , risperidone , ziprasidone , zotepine )Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )Tetracyclic antidepressants (e.g., amoxapine , loxapine , maprotiline , mianserin , mirtazapine , oxaprotiline )Tricyclic antidepressants (e.g., amitriptyline , butriptyline , clomipramine , desipramine , dosulepin (dothiepin) , doxepin , imipramine , iprindole , lofepramine , nortriptyline , protriptyline , trimipramine )Typical antipsychotics (e.g., chlorpromazine , flupenthixol , fluphenazine , loxapine , perphenazine , prochlorperazine , thioridazine , thiothixene )
H2
H3
H4
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